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While topical applications of GHK-Cu in cosmetics may remain largely unaffected, the injectable and compounded forms will be subject to the new Category 2 restrictions

Gastrointestinal effects such as nausea, vomiting, and diarrhea may arise, particularly at the start of treatment or after a dose increase

Nonmotor symptoms, including autonomic dysfunction, cognitive decline, and psychological disturbances, further highlight the systemic impact of PD and its pathophysiology [6,7]

It would be then of great advantage to have a shared methodology concerning the pre-analytical stage (sample preparation and storage), the analytical stage (analysis execution) or assay-related (intrinsic assay quality), in order to compare the BDNF levels